MovDisordV3, Main, Exploration, bibRecord, 003508

Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel‐based morphometry study

Identifieur interne : 003508 ( Main/Exploration ); précédent : 003507; suivant : 003509

Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel‐based morphometry study

Auteurs : Christian Brenneis [Autriche] ; Sylvia M. Boesch [Autriche] ; Karl E. Egger [Autriche] ; Klaus Seppi [Autriche] ; Christoph Scherfler [Autriche] ; Michael Schocke [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-02.

RBID : ISTEX:BFCE1BCD5450D4A8A8D5557A9C0514C3EDDC5CE1

Descripteurs français

Pascal (Inist)
- Ataxie spinocérébelleuse, Atrophie multisystématisée, Cervelet, Morphométrie, Système nerveux pathologie, Voxel.

English descriptors

KwdEn :
- Adult, Aged, Atrophy, Cerebellar Ataxia (diagnosis), Cerebellum, Cerebellum (pathology), Cerebral Cortex (pathology), Diagnosis, Differential, Dominance, Cerebral (physiology), Female, Humans, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging, Male, Mathematical Computing, Mesencephalon (pathology), Middle Aged, Morphometry, Multiple System Atrophy (diagnosis), Multiple system atrophy, Nervous system diseases, Pons (pathology), SCA2, Spinocerebellar Ataxias (diagnosis), Spinocerebellar ataxia, Voxel, atrophy pattern, multiple‐system atrophy, voxel‐based morphometry.
MESH :
- diagnosis : Cerebellar Ataxia, Multiple System Atrophy, Spinocerebellar Ataxias.
- pathology : Cerebellum, Cerebral Cortex, Mesencephalon, Pons.
- physiology : Dominance, Cerebral.
- Adult, Aged, Atrophy, Diagnosis, Differential, Female, Humans, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging, Male, Mathematical Computing, Middle Aged.

Abstract

This study aimed to determine in vivo the atrophy patterns in clinically established cerebellar variant of multiple‐system atrophy (MSA‐C) using voxel‐based morphometry (VBM). Thirteen patients with MSA‐C (12 probable, 1 possible) and 13 healthy controls matched for age and sex were included. High‐resolution MR images were acquired with a 1.5 T scanner. Images were normalized onto a study‐specific template, segmented into the tissue compartments, modulated with the Jacobian determinants, and finally smoothed with a Gaussian kernel filter of 10 mm. The general linear model was used to assess statistical differences in gray and white matter. Infratentorial atrophy was observed in the cerebellar hemispheres, vermis, mesencephalon, and pons of MSA‐C patients. Supratentorial volume loss was found in orbitofrontal and mid‐frontal regions as well as in temporomesial and insular areas of both hemispheres. A negative correlation was observed between a cerebellar ataxia score and the volume of cerebellar hemispheres, peduncles, and pons. To compare this atrophy pattern to that of spinocerebellar ataxia (SCA2), which was previously reported by our group, a conjunction analysis was assessed. We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid‐frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/BFCE1BCD5450D4A8A8D5557A9C0514C3EDDC5CE1/fulltext/pdf

DOI: 10.1002/mds.20656

Affiliations:

Le document en format XML

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<term>Cerebellum</term>
<term>Cerebellum (pathology)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Diagnosis, Differential</term>
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<term>Morphometry</term>
<term>Multiple System Atrophy (diagnosis)</term>
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<term>Aged</term>
<term>Atrophy</term>
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<front><div type="abstract" xml:lang="en">This study aimed to determine in vivo the atrophy patterns in clinically established cerebellar variant of multiple‐system atrophy (MSA‐C) using voxel‐based morphometry (VBM). Thirteen patients with MSA‐C (12 probable, 1 possible) and 13 healthy controls matched for age and sex were included. High‐resolution MR images were acquired with a 1.5 T scanner. Images were normalized onto a study‐specific template, segmented into the tissue compartments, modulated with the Jacobian determinants, and finally smoothed with a Gaussian kernel filter of 10 mm. The general linear model was used to assess statistical differences in gray and white matter. Infratentorial atrophy was observed in the cerebellar hemispheres, vermis, mesencephalon, and pons of MSA‐C patients. Supratentorial volume loss was found in orbitofrontal and mid‐frontal regions as well as in temporomesial and insular areas of both hemispheres. A negative correlation was observed between a cerebellar ataxia score and the volume of cerebellar hemispheres, peduncles, and pons. To compare this atrophy pattern to that of spinocerebellar ataxia (SCA2), which was previously reported by our group, a conjunction analysis was assessed. We observed a volume loss shared by both disorders comprising the cerebellum, vermis, pons, mesencephalon, orbitofrontal, mid‐frontal, and temporomesial cortex of both hemispheres as well as the left insular cortex. © 2005 Movement Disorder Society</div>
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Movement Disorders (revue)

Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel‐based morphometry study

Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel‐based morphometry study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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